Progressive Supranuclear Palsy Research Paper Example | Topics and Well Written Essays - 1500 words

Progressive Supranuclear Palsy - Research Paper Example Men are known to be affected by this condition to a greater extent as compared to the females (Golbe and Ohman-Strickland, 2007). Clinical Presentation The PSP encompasses distinguishing mild dementia, lack of memory, sluggishness of contemplation procedure, poignant or behavior modifications encompassing lethargy or hopelessness with infrequent outbreaks or petulance and weaken capability to maneuver attained information, the condition leads to subcortical dementia, the characteristic feature of PSP. The clinical features include parkinsonism, though with rigidity in extension rather than flexion and tremor is usually minimal. In addition there must be a supranuclear paralysis of eye movements, usually downgaze for the appropriate diagnosis. These features are accompanied by pyramidal signs and cognitive impairment. The condition belongs to the family of taupathies and engross both cortical and subcortical structures (Stamelou et al, 2010). PSP is a symmetric, akinetic-rigid syndrom e, frontal shortfalls, postural instability as well as falls. Early gait interruption with sub-zero, micrographia and hypophonia comprise an additional deviation entitled pure akinesia with gait freezing (Williams and Lee, 2009). Observations reveal that in case of progressive supranuclear palsy, cortical lesions play an imperative role in highlighting the symptoms and signs of the disease. The patient thus presents supranuclear opthalmoplegia. Apart from these features, additional clinical characteristics involve, progressive asymmetric dystonia, apraxia and cortical sensory loss (PSP-corticobasal syndrome) (Josephs et al, 2005). The heterogeneity of the medical management emerges to trail distinction in the anatomical allocation of diverse, PSP-specific histopathological amendments (Willians and Lees, 2009). These features are supported with retrospective neuropathological research. Neuropathology Neuropathologically, PSP is defined as an accumulation of neurofibrillary tangles an d thereby loss of neuronal cells encompasses cortical and subcortical constitution, in particular the subthalamic nuclei, globus pallidus, red nucleus, superior colliculi, pretectal regions, periaqueductal grey matter, substantia nigra, thalamus, cerebellum, the entire pontine tegmentum, oculomotor nucleus, medulla, dentate nucleus and the spinal cord (Williams and Lees, 2009). Cases which do not predispose these features are difficult to diagnose. Research studies reveal that genetic mutations in the tau gene present on the chromosome 17 is responsible for the frontotemporal dementias. Stanford et al (2000), have identified that a silent mutation (S305S) in the tau gene is responsible for noteworthy atrophy or cellular collapse of the frontal and temporal cortices. Histopathological tests display intracellular, somatodendritic tau-aggregates which are shown by the silver staining (Dickson, 1999). Presence of neurofibrillary tangles in neurons, neuropil threads in neuronal processes , coiled twisting bodies in oligodendrocytes, tufted astrocytes in the basal ganglia, amygdala and motor cortex as well as nonexistence of neuritic plaques aid to discriminate PSP from other tauopathies. Taupathies is a common terminology employed to neurodegenerative disorders displaying tau-pathology in the glial or neuronal cells. Tau protein is expressed in neurons, associated with the microtubule.

Impact of Social Networking and Blogging on Internet Usage Essay

Impact of Social Networking and Blogging on Internet Usage - Essay Example These are just limited uses of blogging and social networking. The wide spectrum of using these interactivities online entails that blogging and social networking bring people closer and turning the world into a global village where there are no distances (Jacqui 2010). Introduction Social networking has become an integral part of millions of Internet users around the world. When people come back to home from their work places and educational institutes, the first thing most of them prefer to do is to check their personal profiles on social networking websites, such as Facebook, Twitter and many others. They find it a facilitating medium for interacting with hundreds of people within and outside their national borders. Social network or social networking websites actually provides Internet user a virtual interface where they can share their ideas and thoughts. The social networking websites are usually used for studying the social relationships of people. The term social networking d escribes a person’s or group of persons’ social structure and is determined with the help of their communication and interaction with others (Lusted 2011, Aleman and Wartman 2009). On the other hand, blogs or blogging websites provides a personal space to Internet users where they can lodge their posts, ides, believes and views on certain issues, keeping in view the area of interest. Blogs usually contain write-up of a person, group of personals or organization aiming to discuss a single agenda subject. Scholars and web technologists first utilized blogs in 90s and to post content containing ideas and beliefs of these scholars and technologists. Since then, non-technical users are using blogs as well (Rettberg 2008). Social media and blogs has attracted masses towards utilizing these internet tools to share ideas, market their products and services and help out individuals who are looking for solutions to their problems, let it be professional or academic one. A resear ch conducted by University of Maryland reveals that people across the globe are becoming addicted to using social networking sites and blogs. Social media especially has become a major source of communicating with rest of the world. The academic research conducted on understanding how the social networking sites are reshaping the behavior states that Facebook, world’s most used social networking website, has become a primary source of communication among students. On professional level, social networking and blogging is utilized extensively for providing business solutions and discussing new technologies and innovations. In broader spectrum, Internet usage has increased after the introduction of blogging and social networking websites and the analysis of statistical data shows that it is expected to increase even more. Academic Usage of Internet Societies and individuals living in these societies are of the view that their internet usage has increased since the arrival of inf otainment add ons like Facebook, Twitter, Blogger Online, Flickr, and others (Ishak 2010). This is because these individuals can share their precious moments with others, and also, take guidance and suggestions regarding the problems and issues they are facing. Students goes to social networking sites and blogs at least four times a day in order to keep in touch with their friends, to ask their teachers for solutions to